Cialis with Dapoxetine is a medical product intended for the treatment of erectile dysfunction, that is, the inability to achieve and maintain the erection necessary to perform sexual intercourse.
Pharmachologic effect of Cialis with Dapoxetine
Cialis with Dapoxetine is an effective, reversible selective inhibitor (selective neutralizer) of specific phosphodiesterase type 5 (PDE5) cyclic guanosine monophosphate (cGMP). When sexual arousal causes local release of nitric oxide, the inhibition of PDE5 by tadalafil leads to an increase in cGMP levels in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and the flow of blood to the tissues of the penis, which causes an erection. Tadalafil has no effect in the absence of sexual stimulation.
Cialis with Dapoxetine improves the erection and the possibility of a successful sexual intercourse. The drug is valid for 36 hours. The effect is manifested as early as 16 minutes after taking the drug in the presence of sexual arousal.
Tadalafil in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the lying position (the average maximum decrease is 1, 6/0, 8 mm Hg, respectively) and in the standing position (the average maximum decrease is 0, 2/4, 6 mm Hg, respectively).
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Indications for use
To date, Tadalafil has only one indication for use – it is treatment of erectile dysfunction, that is, a condition in which the penis does not become sufficiently dense and excited for a full intimate contact. The drug leads to the development of a good erection only in combination with sexual stimulation.
Tadalafil is indicated for use with a weak erection caused by the following factors:
- psychoemotional disorders;
- organic erectile dysfunction;
- diabetes;
- distant prostate gland;
- obesity;
- hypertension;
- spinal cord injury.