Pharmacological effect of Dutahair
A remedy for the treatment of benign prostatic hyperplasia. Suppresses the activity of isoenzymes of 5α-reductase 1 and 2, which are responsible for converting testosterone into 5α-dihydrotestosterone. Dutahair is the main androgen responsible for the hyperplasia of the glandular tissue of the prostate gland.
The maximum effect of Dutahair on the decrease in the concentration of dihydrotestosterone depends on the dose and is observed after 1-2 weeks. After the beginning of treatment. After 1 and 2 weeks. Dutasteride at a dose of 0.5 mg / day, the average concentration of dihydrotestosterone in the serum is reduced by 85% and 90%.
Dutasteride (Avodart) helps to reduce the size of the prostate gland, improves urination and reduces the risk of acute urine retention and the need for surgical treatment.
Contraindications
- Dutahair is contraindicated in patients with hypersensitivity to it, other 5-alpha-reductase inhibitors or any ingredient in this drug.
- Dutahair is contraindicated in women, children and adolescents.
- Dutahair is contraindicated in patients with severe hepatic insufficiency.
Dosing and Administration
Dutahair can be used in the form of monotherapy, as well as in combination with an adrenoblocker tamsulosin.
Dutasteride can be taken regardless of food intake.
The effect comes fairly quickly, but treatment should be continued for at least 6 months in order to objectively evaluate the effect of the drug.
Adult men (including the elderly)
The recommended dose of dutasteride is one capsule (0.5 mg) once a day orally. Capsules should be swallowed whole, not chewed, not opened, as the contents of the capsule can cause irritation of the mucous membrane of the oropharynx.
Patients with impaired renal function
When taking 0.5 mg of dutasteride per day, less than 0.1% of the dose is excreted in the urine, therefore, dose adjustments in patients with impaired renal function are not required.
Patients with hepatic impairment
Dutahair is subject to intensive metabolism, and its half-life is 3-5 weeks, and therefore caution should be exercised in treating dutasteride in patients with impaired hepatic function.