Frusenex is a medicament, a diuretic.
Dosage form of Frusenex
Granules for preparation of suspension for oral administration (for children), solution for intravenous and intramuscular administration, tablets.
Contraindications of Frusenex
Hypersensitivity, acute renal failure with anuria (glomerular filtration value less than 3-5 ml / min), severe hepatic insufficiency, hepatic coma and precoma, stenosis of the urethra, acute glomerulonephritis, urinary stone obstruction, precomatitis, hyperglycemic coma, hyperuricemia, gout , decompensated mitral or aortic stenosis, GOKMP, increased central venous pressure (> 10 mm Hg), arterial hypotension, acute myocardial infarction, pancreatitis, narcosis shenie water-electrolyte metabolism (hypovolemia, hyponatremia, hypokalemia, hypochloremia, hypocalcemia, hypomagnesemia), digitalis intoxication.
With caution. Hyperplasia of the prostate, SLE, hypoproteinemia (risk of ototoxicity development), diabetes mellitus (decrease in glucose tolerance), stenosing cerebral arteries atherosclerosis, pregnancy (especially the first half, possible use according to vital indications), lactation period.
Dosing regimen
Intravenous (rarely intramuscularly), parenteral administration is advisable to carry out in those cases when there is no possibility of taking it inside – in urgent situations or with a pronounced edematous syndrome. Puff syndrome: the initial dose is 40 mg. Intravenous administration is carried out for 1-2 minutes; in the absence of a diuretic response every 2 hours, injected in an increased 50% dose until an adequate diuresis is achieved. The average daily dose for intravenous administration in children is 0.5-1.5 mg / kg, the maximum dose is 6 mg / kg. Patients with reduced glomerular filtration and low diuretic response are prescribed in large doses – 1-1.5 g. The maximum single dose is 2 g. Inside, in the morning, before meals, the average single initial dose is 20-80 mg; in the absence of a diuretic response, the dose is increased by 20-40 mg every 6-8 hours until an adequate diuretic response is obtained. A single dose, if necessary, can be increased to 600 mg or more (required with a decrease in glomerular filtration and hypoproteinemia). With arterial hypertension, 20-40 mg is prescribed, in the absence of a sufficient reduction in blood pressure, other antihypertensive drugs must be added to the treatment. When Furosemide (Lasix) is added to the already prescribed antihypertensive drugs, their dose should be reduced by a factor of 2. The initial single dose in children is 2 mg / kg, the maximum dose is 6 mg / kg.