Category: Hormones & Peptides
Package: 5000 iu vial
Manufacturer: Sun Pharmaceuticals
Pharmacologic effect of Fertigyn (Pregnyl)
The active substance of the rot is human chorionic gonadotropin, which is obtained from the urine of pregnant women. Fertigyn stimulates the formation of steroid hormones in the sex glands due to the effect of the human luteinizing hormone. In females, the drug causes an increase in the synthesis of progesterone and estrogens after ovulation; in male patients, pregnil stimulates the synthesis of testosterone. The appearance of antibodies against human chorionic gonadotropin in the body was not observed with the introduction of pregnal.
The maximum concentration of human chorionic gonadotropin in blood plasma in women is determined in 20 hours, in men – after 6 hours (after injection intramuscularly once). Significant differences in pharmacokinetics in men and women are mainly due to the greater thickness of subcutaneous fat in women in the buttock area. After intramuscular injection, HCG is absorbed into the blood well. The half-life of the decay is 33 hours. Approximately 80% of the drug is destroyed in the kidney tissue. Elimination – with urine.
Mode of application of Fertigyn
Prior to the introduction into the lyophilized active substance of the decolour, the attached solvent is added. Administer intramuscularly slowly. The prepared solution is not subject to storage, since further preservation of the sterility of the solution is not guaranteed. The indicated dosages are approximate, the treatment should be adjusted by the doctor individually depending on the necessary reaction to the introduction of the decay.
Preparation of the follicle for puncture or induction of ovulation: once injected with a dosage of 3000-10 000 IU.
Support for the luteal phase of the menstrual cycle: dosage 1000-3000 IU once a day. A total of 2-3 injections are given: every 1 time in 9 days after the moment of embryo implantation or after ovulation (for example: after stimulation of ovulation on days 3, 6 and 9).
When male infertility due to violations of the process, spermatogenesis is prescribed in combination with follicle-stimulating hormone 1 time per day or 2-3 times a week for at least 3 months before increasing the qualitative and quantitative parameters of the spermogram. Can be used as a monotherapy. The drug is prescribed for 1000-2000 IU. During the introduction of the fungus, it is necessary to temporarily stop the substitution treatment with testosterone, if any.
Delayed sexual development in boys – the worst is prescribed in a dose of 1500 IU, the course of treatment – at least 6 months. The drug is administered 2-3 times a week.
Cryptorchidism: for children under 2 years of age, a dose of 250 IU is administered twice a 7 days with a course of at least 6 months; from 2 to 6 years – 2 times per 7 days for 500-1000 IU course of 6 months; for children more than 6 years – 2 times per 7 days for 6 months to 1500 IU. In case of insufficient effect, the course of treatment can be repeated.